Publications | Mysite

2023

38. N. A. Yusoh, P. R. Tiley, S. D. James, S. N. Harun, J. A. Thomas, N. Saad, L-W, Hii, S. L. Chia, M.R. Gill, H. Ahmad, Discovery of Ruthenium(II) Metallocompound and Olaparib Synergy for Cancer Combination Therapy, J. Med. Chem., 2023, 66, 10, 6922–6937.

https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.3c00322

37. C. Xiong, H. Chen, J. Zhang, H. Deng, Z. Feng, P. Xiang, Y. Tian, L. Chen, M. R. Gill, X. Tian, A bipyridyl quinoline ruthenium(Ⅱ) complex as a “Light Switch” for living cell mitochondrial singlet oxygen, Sens. Actuators B: Chem, 2023, 388, 133868
Volume 388, 1 August 2023, 133868

https://www.sciencedirect.com/science/article/pii/S092540052300583X

36. N. A. Yusoh, S. L. Chia, N. Saad, H. Admad, M. R. Gill, Synergy of ruthenium metallo-intercalator, [Ru(dppz)2(PIP)]2+, with PARP inhibitor Olaparib in non-small cell lung cancer cells, Sci. Rep., 2023, 13, 1456.

https://www.nature.com/articles/s41598-023-28454-x

35. C. E. Elgar, N. A. Yusoh, P. R. Tiley, N. Kolozsvári, L. G. Bennett, A. Gamble, E. V. Péan, M. L. Davies, C. J. Staples, H. Ahmad, M. R. Gill, Ruthenium(II) Polypyridyl Complexes as FRET Donors: Structure- and Sequence-Selective DNA-Binding and Anticancer Properties, J. Am. Chem. Soc., 2023, 145, 2, 1236-1246.

https://pubs.acs.org/doi/10.1021/jacs.2c11111

2022

34. M. R. Gill, P. J. Jarman, V. Hearnden, S. D. Fairbanks, M. Bassetto, J. Palmer, K. R. Ayscough, J. A. Thomas, C. Smythe, A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis, Angew. Chem. Int. Ed., 2022, 61, 27, e202117449

https://onlinelibrary.wiley.com/doi/10.1002/anie.202117449

2021

33. B. M. Bavelaar, L. Song, M. R. Jackson, S. Able, O. Tietz, I. Skaripa-Koukelli, P. A. Waghorn, M. R. Gill, R. C. Carlisle, M. Tarsounas, K. A. Vallis, Oligonucleotide-Functionalized Gold Nanoparticles for Synchronous Telomerase Inhibition, Radiosensitization, and Delivery of Theranostic Radionuclides, Mol. Pharmaceutics, 2021, 18, 10, 3820-3831. https://doi.org/10.1021/acs.molpharmaceut.1c00442

32. E. D. M. Isa, H. Ahmad, M. B. A. Rahman, M. R. Gill, Progress in mesoporous silica nanoparticles as drug delivery agents for cancer treatment, Pharmaceutics, 2021, 13, 152. https://www.mdpi.com/1999-4923/13/2/152

31. S. N. Harun, H. Ahmad, H. N. Lim, S. L. Chia, M. R. Gill, Synthesis and optimization of mesoporous silica nanoparticles for ruthenium polypyridyl drug delivery, Pharmaceutics, 2021, 13, 150. https://www.mdpi.com/1999-4923/13/2/150

2020

30. N. A. Yusoh, H. Ahmad, M. R. Gill, Combining PARP inhibition with platinum, ruthenium or gold metal complexes for cancer therapy, ChemMedChem, 2020, 15, 2121-2135.

https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.202000391

29. N. A. Yusoh, S. W. Leong, S. L. Chia, S. N. Harun, M. B. A. Rahman, K. A. Vallis, M. R. Gill, H. Ahmad, The metallo-intercalator [Ru(dppz)2(PIP)]2+ renders BRCA wild-type triple-negative breast cancer cells hypersensitive to PARP inhibition, ACS Chem Biol, 2020, 15, 378-387. https://pubs.acs.org/doi/10.1021/acschembio.9b00843

28. M. R. Gill, M. G. Walker, S. Able, Ole Tietz, A. Lakshminarayanan, R. Anderson, R. Chalk, A. H. El-Sagheer, T. Brown, J. A. Thomas, K. A. Vallis, An 111In-labelled bis-ruthenium(II) dipyridophenazine theranostic complex: Mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells. Chem Sci, 2020, 11, 8936-8944.

https://pubs.rsc.org/en/content/articlelanding/2020/sc/d0sc02825h#!divAbstract

27. J. Owen, E. Thomas, J. Menon, M. Gray, I. Skaripa-Koukelli, M. R. Gill, S. Wallington, R. L. Miller, K. A. Vallis, R. Carlisle, Indium-111 labelling of liposomal HEGF for radionuclide delivery via ultrasound-induced cavitation, J Control Release, 2020, 319, 222-233. https://www.sciencedirect.com/science/article/abs/pii/S0168365919307643

2019

26. M. R. Jackson, B. M. Bavelaar, P. A. Waghorn, M. R. Gill, A. H. El-Sagheer, T. Brown, M. Tarsounas, K. A. Vallis, Dual-action 111In-labelled oligonucleotides against the RNA subunit of telomerase inhibit enzymatic activity and are radiotoxic against telomerase-positive cancer cells, Cancer Res, 2019, 79, 4627-4637. https://cancerres.aacrjournals.org/content/79/18/4627

25. P. Brown, RELISH consortium, Y. Zhou, Large expert-curated database for benchmarking document similarity detection in biomedical literature search, Database, 2019, 1-66.

24. Y. Zhu, M. Zhang, L. Luo, M. R. Gill, C. De Pace, G. Battaglia, Q. Zhang, H. Zhou, J. Wu, T. Tian, X. Tian, NF-kB hijacking theranostic Pt(II) complex in cancer therapy, Theranostics, 2019, 9, 2158-2166. https://www.thno.org/v09p2158

23. K. Smitten, H. Southam, J. Bernardino de la Serna, M. R. Gill, P. Jarman, C. Smythe, R. Poole, J. A. Thomas, Using nanoscopy to probe the biological activity of antimicrobial lead compounds that display potent activity against pathogenic, multi-drug resistant, Gram-negative bacteria, ACS Nano, 2019, 13, 5133-5146. https://pubs.acs.org/doi/10.1021/acsnano.8b08440

22. M. R. Gill and K. A. Vallis, Transition metal compounds as cancer radiosensitizers, Chem. Soc. Rev, 2019, 48, 540 – 557.

https://pubs.rsc.org/en/content/articlelanding/2019/cs/c8cs00641e#!divAbstract

2018

21. B. M. Bavelaar, B. Q. Lee, M. R. Gill, N. Falzone, K. A. Vallis, Subcellular targeting of theranostic radionuclides, Front. Pharmacol., 2018, 9, 996.

https://www.frontiersin.org/articles/10.3389/fphar.2018.00996/full

20. M. R. Gill,† J. U. Menon,† P. Jarman, J. Owen, I. Sharipa-Koukelli, S. Able, J. A. Thomas, R. Carlisle, K. A. Vallis, 111In-labelled polymeric nanoparticles incorporating a ruthenium-based radiosensitizer for EGFR-targeted combination therapy in oesophageal cancer cells, Nanoscale, 2018, 10, 10596-10608.

https://pubs.rsc.org/en/content/articlelanding/2018/nr/c7nr09606b#!divAbstract

19. M. R. Gill, P. Jarman, S. Halder, M.G. Walker, J. A. Thomas, C. Smythe, K. Ramadan, K. A. Vallis, A three-in-one bullet for oesophageal cancer: Replication fork collapse, spindle attachment failure and enhanced radiosensitivity generated by a ruthenium(II) metallo-intercalator, Chem. Sci., 2018, 9, 841-849. https://pubs.rsc.org/en/content/articlelanding/2018/sc/c7sc03712k#!divAbstract

2017

18. S. Sreedharan, M. R. Gill, E. Garcia, H. K. Saeed, D. Robinson, A. Byrne, A. Cadby, T. E. Keyes, C. Smythe, P. Pellett, J. B. de la Serna, J. A. Thomas, Multimodal super-resolution optical microscopy using a transition metal-based probe provides unprecedented capabilities for imaging both nuclear chromatin and mitochondria, J. Am. Chem. Soc., 2017, 139, 15907–15913. https://pubs.acs.org/doi/abs/10.1021/jacs.7b08772

17. M. R. Gill, N. Falzone, Y. Du, K. A. Vallis, Targeted radionuclide therapy in combined-modality regimens, Lancet Oncol., 2017, 18, e414–e423.

https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(17)30379-0/fulltext

2016

16. M. R. Gill, S. N. Harun, S. Halder, R. A. Boghozian, K. Ramadan, H. Ahmad, K. A. Vallis, A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition, Sci. Rep., 2016, 6, 31973.

https://www.nature.com/articles/srep31973

15. M. G. Walker, P. J. Jarman, M. R. Gill, X. Tian, H. Ahmad, P. A. N. Reddy, L. McKenzie, J. A. Weinstein, A. J. R. Meijer, G. Battaglia, C. Smythe and J. A. Thomas, A self-assembled metallomacrocycle singlet oxygen sensitizer for photodynamic therapy, Chem. Eur. J., 2016, 22, 5996-6000. https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201600852

2015

14. A. Wragg,† M. R. Gill,† L. McKenzie, C. Glover, R. Mowll, X. Su, C. Smythe and J. A. Thomas, Serum albumin binding inhibits nuclear uptake of luminescent metal complex-based DNA imaging probes, Chem. Eur. J., 2015, 21, 11865-11871.

https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201501675

13. V. Ramu,† M. R. Gill,† P. J. Jarman, D. Turton, J. A. Thomas, A. Das and C. Smythe, A cytostatic ruthenium(II)-platinum(II) bis(terpyridyl) anticancer complex that blocks entry into S phase through up-regulating p27KIP1, Chem. Eur. J., 2015, 21, 9185-9197.

https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201500561

2014

12. A. Wragg,† M. R. Gill,† D. Turton, H. Adams, C. Smythe, X. Su and J. A. Thomas, Tuning the cellular uptake properties of luminescent heterobimetallic iridium(III)-ruthenium(II) DNA imaging probes, Chem. Eur. J., 2014, 20, 14004-14011.

https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201403693

11. A. Wragg, M. R. Gill, C. J. Hill, X. Su, A. J. H. M. Meijer, C. Smythe and J. A. Thomas, Dinuclear osmium(II) probes for high-resolution visualisation of cellular DNA structure using electron microscopy, Chem. Commun., 2014, 50, 14494-14497 (front cover).

https://pubs.rsc.org/en/content/articlelanding/2014/cc/c4cc05547k#!divAbstract

10. E. Baggaley, M. R. Gill, N. H. Green, D. Turton, I. V. Sazanovich, S. W. Botchway, C. Smythe, J. W. Haycock, J. A. Weinstein, J. A. Thomas, Dinuclear ruthenium(II) complexes as two-photon, time-resolved emission microscopy probes for cellular DNA, Angew. Chem. Int. Ed., 2014, 53, 3367-3371 (front cover; Faculty of 1000 recommended article).

https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201309427

2013

9. M. R. Gill, D. Cecchin, M. G. Walker, R. S. Mulla, G. Battaglia, C. Smythe and J. A. Thomas, Targeting the endoplasmic reticulum with a membrane-interactive luminescent ruthenium(II) polypyridyl complex, Chem. Sci., 2013, 4, 4512-4519. (referee-recommended "hot article"). https://pubs.rsc.org/en/content/articlelanding/2013/SC/c3sc51725j#!divAbstract

2012

8. M. R. Gill and J. A. Thomas, Ruthenium(II) polypyridyl complexes and DNA: from structural probes to cellular imaging and therapeutics, Chem. Soc. Rev., 2012, 41, 3179-3192.

https://pubs.rsc.org/en/content/articlelanding/2012/CS/c2cs15299a#!divAbstract

2007-2011 (PhD w. Profs J. Thomas and G. Battaglia):

7. M. R. Gill, H. Derrat, C. Smythe, G. Battaglia and J. A. Thomas, Ruthenium(II) metallo-intercalators: DNA imaging and cytotoxicity, ChemBioChem, 2011, 12, 877-880 (a ChemBioChem “most cited” article 2012-13).

https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201000782

6. X. Tian, M. R. Gill, I. Canton, J. A. Thomas and G. Battaglia, Live cell luminescence imaging as a function of delivery mechanism, ChemBioChem, 2011, 12, 548-551. https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201000743

5. A. Ghosh, P. Das, M. R. Gill, P. Kar, M. G. Walker, J. A. Thomas and A. Das, Photoactive RuII–Polypyridyl Complexes that Display Sequence Selectivity and High-Affinity Binding to Duplex DNA through Groove Binding, Chem. Eur. J., 2011, 17, 2089-2098 (inside cover). https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201002149

4. P. Waywell, V. Gonzalez, M. R. Gill, H. Adams, A. J. H. Meijer, M. P. Williamson and J. A. Thomas, Structure of the Complex of [Ru(tpm)(dppz)py]2+ with a B-DNA Oligonucleotide - A Single-Substituent Binding Switch for a Metallo-Intercalator, Chem. Eur. J., 2010, 16, 2407-2417. (inside cover). https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.200901758

3. M. R. Gill, J. Garcia-Lara, S. J. Foster, C. Smythe, G. Battaglia and J. A. Thomas, A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells, Nature Chem., 2009, 1, 662-667. https://www.nature.com/articles/nchem.406

2. S. P. Foxon, T. Phillips, M. R. Gill, M. Towrie, A. W. Parker, M. Webb and J. A. Thomas, A Multifunctional Light Switch: DNA Binding and Cleavage Properties of a Heterobimetallic Ruthenium-Rhenium Dipyridophenazine Complex, Angew. Chem. Int. Ed., 2007, 46, 3686-3688. https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.200604837

BSc:

1. C. J. Adams, J. P. H. Charmant, N. G. Connelly, M. Gill, A. Kantacha, S. Onganusorn and A. G. Orpen, Homobinuclear cyanide-bridged linkage isomers containing the redox-active unit [([μ]-XY)Ru(CO)2L(o-O2C6Cl4)] (XY = CN or NC), Dalton Trans., 2007, 2283-2294. https://pubs.rsc.org/en/content/articlelanding/2007/dt/b700648a#!divAbstract

Book chapters:

M. R. Gill and J. A. Thomas, Targeting cellular DNA with luminescent ruthenium(II) polypyridyl complexes, in Ruthenium Complexes - Photochemical and Biomedical Applications, eds. A. Holder, J. L. Bullock, M. A. Lawrence, W. R. Browne and L. Lilge, Wiley-VCH, 2018.

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