2024
39. S. D. James, C. E. Elgar, D. Chen, M. I. Lewis, E. T. L. Ash, D. S. Conway, B. J. Tuckley, L. E. Phillips, N. Kolozsvári, X. Tian, M. R. Gill, Cyrene(TM) as a green alternative to N,N’-dimethylformamide (DMF) in the synthesis of MLCT-emissive ruthenium(II) polypyridyl complexes for biological applications, Dalton Trans., 2024, 53, 18506 - 18514.
https://pubs.rsc.org/en/content/articlelanding/2024/dt/d4dt02676d
2023
38. N. A. Yusoh, P. R. Tiley, S. D. James, S. N. Harun, J. A. Thomas, N. Saad, L-W, Hii, S. L. Chia, M.R. Gill, H. Ahmad, Discovery of Ruthenium(II) Metallocompound and Olaparib Synergy for Cancer Combination Therapy, J. Med. Chem., 2023, 66, 10, 6922–6937.
https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.3c00322
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37. C. Xiong, H. Chen, J. Zhang, H. Deng, Z. Feng, P. Xiang, Y. Tian, L. Chen, M. R. Gill, X. Tian, A bipyridyl quinoline ruthenium(â…¡) complex as a “Light Switch” for living cell mitochondrial singlet oxygen, Sens. Actuators B: Chem, 2023, 388, 133868
Volume 388, 1 August 2023, 133868
https://www.sciencedirect.com/science/article/pii/S092540052300583X
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36. N. A. Yusoh, S. L. Chia, N. Saad, H. Admad, M. R. Gill, Synergy of ruthenium metallo-intercalator, [Ru(dppz)2(PIP)]2+, with PARP inhibitor Olaparib in non-small cell lung cancer cells, Sci. Rep., 2023, 13, 1456.
https://www.nature.com/articles/s41598-023-28454-x
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35. C. E. Elgar, N. A. Yusoh, P. R. Tiley, N. Kolozsvári, L. G. Bennett, A. Gamble, E. V. Péan, M. L. Davies, C. J. Staples, H. Ahmad, M. R. Gill, Ruthenium(II) Polypyridyl Complexes as FRET Donors: Structure- and Sequence-Selective DNA-Binding and Anticancer Properties, J. Am. Chem. Soc., 2023, 145, 2, 1236-1246.
https://pubs.acs.org/doi/10.1021/jacs.2c11111
2022
34. M. R. Gill, P. J. Jarman, V. Hearnden, S. D. Fairbanks, M. Bassetto, J. Palmer, K. R. Ayscough, J. A. Thomas, C. Smythe, A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis, Angew. Chem. Int. Ed., 2022, 61, 27, e202117449
https://onlinelibrary.wiley.com/doi/10.1002/anie.202117449
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2021
33. B. M. Bavelaar, L. Song, M. R. Jackson, S. Able, O. Tietz, I. Skaripa-Koukelli, P. A. Waghorn, M. R. Gill, R. C. Carlisle, M. Tarsounas, K. A. Vallis, Oligonucleotide-Functionalized Gold Nanoparticles for Synchronous Telomerase Inhibition, Radiosensitization, and Delivery of Theranostic Radionuclides, Mol. Pharmaceutics, 2021, 18, 10, 3820-3831. https://doi.org/10.1021/acs.molpharmaceut.1c00442
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32. E. D. M. Isa, H. Ahmad, M. B. A. Rahman, M. R. Gill, Progress in mesoporous silica nanoparticles as drug delivery agents for cancer treatment, Pharmaceutics, 2021, 13, 152. https://www.mdpi.com/1999-4923/13/2/152
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31. S. N. Harun, H. Ahmad, H. N. Lim, S. L. Chia, M. R. Gill, Synthesis and optimization of mesoporous silica nanoparticles for ruthenium polypyridyl drug delivery, Pharmaceutics, 2021, 13, 150. https://www.mdpi.com/1999-4923/13/2/150
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2020
30. N. A. Yusoh, H. Ahmad, M. R. Gill, Combining PARP inhibition with platinum, ruthenium or gold metal complexes for cancer therapy, ChemMedChem, 2020, 15, 2121-2135.
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.202000391
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29. N. A. Yusoh, S. W. Leong, S. L. Chia, S. N. Harun, M. B. A. Rahman, K. A. Vallis, M. R. Gill, H. Ahmad, The metallo-intercalator [Ru(dppz)2(PIP)]2+ renders BRCA wild-type triple-negative breast cancer cells hypersensitive to PARP inhibition, ACS Chem Biol, 2020, 15, 378-387. https://pubs.acs.org/doi/10.1021/acschembio.9b00843
28. M. R. Gill, M. G. Walker, S. Able, Ole Tietz, A. Lakshminarayanan, R. Anderson, R. Chalk, A. H. El-Sagheer, T. Brown, J. A. Thomas, K. A. Vallis, An 111In-labelled bis-ruthenium(II) dipyridophenazine theranostic complex: Mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells. Chem Sci, 2020, 11, 8936-8944.
https://pubs.rsc.org/en/content/articlelanding/2020/sc/d0sc02825h#!divAbstract
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27. J. Owen, E. Thomas, J. Menon, M. Gray, I. Skaripa-Koukelli, M. R. Gill, S. Wallington, R. L. Miller, K. A. Vallis, R. Carlisle, Indium-111 labelling of liposomal HEGF for radionuclide delivery via ultrasound-induced cavitation, J Control Release, 2020, 319, 222-233. https://www.sciencedirect.com/science/article/abs/pii/S0168365919307643
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2019
26. M. R. Jackson, B. M. Bavelaar, P. A. Waghorn, M. R. Gill, A. H. El-Sagheer, T. Brown, M. Tarsounas, K. A. Vallis, Dual-action 111In-labelled oligonucleotides against the RNA subunit of telomerase inhibit enzymatic activity and are radiotoxic against telomerase-positive cancer cells, Cancer Res, 2019, 79, 4627-4637. https://cancerres.aacrjournals.org/content/79/18/4627
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25. P. Brown, RELISH consortium, Y. Zhou, Large expert-curated database for benchmarking document similarity detection in biomedical literature search, Database, 2019, 1-66.
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24. Y. Zhu, M. Zhang, L. Luo, M. R. Gill, C. De Pace, G. Battaglia, Q. Zhang, H. Zhou, J. Wu, T. Tian, X. Tian, NF-kB hijacking theranostic Pt(II) complex in cancer therapy, Theranostics, 2019, 9, 2158-2166. https://www.thno.org/v09p2158
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23. K. Smitten, H. Southam, J. Bernardino de la Serna, M. R. Gill, P. Jarman, C. Smythe, R. Poole, J. A. Thomas, Using nanoscopy to probe the biological activity of antimicrobial lead compounds that display potent activity against pathogenic, multi-drug resistant, Gram-negative bacteria, ACS Nano, 2019, 13, 5133-5146. https://pubs.acs.org/doi/10.1021/acsnano.8b08440
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22. M. R. Gill and K. A. Vallis, Transition metal compounds as cancer radiosensitizers, Chem. Soc. Rev, 2019, 48, 540 – 557.
https://pubs.rsc.org/en/content/articlelanding/2019/cs/c8cs00641e#!divAbstract
2018
21. B. M. Bavelaar, B. Q. Lee, M. R. Gill, N. Falzone, K. A. Vallis, Subcellular targeting of theranostic radionuclides, Front. Pharmacol., 2018, 9, 996.
https://www.frontiersin.org/articles/10.3389/fphar.2018.00996/full
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20. M. R. Gill,† J. U. Menon,† P. Jarman, J. Owen, I. Sharipa-Koukelli, S. Able, J. A. Thomas, R. Carlisle, K. A. Vallis, 111In-labelled polymeric nanoparticles incorporating a ruthenium-based radiosensitizer for EGFR-targeted combination therapy in oesophageal cancer cells, Nanoscale, 2018, 10, 10596-10608.
https://pubs.rsc.org/en/content/articlelanding/2018/nr/c7nr09606b#!divAbstract
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19. M. R. Gill, P. Jarman, S. Halder, M.G. Walker, J. A. Thomas, C. Smythe, K. Ramadan, K. A. Vallis, A three-in-one bullet for oesophageal cancer: Replication fork collapse, spindle attachment failure and enhanced radiosensitivity generated by a ruthenium(II) metallo-intercalator, Chem. Sci., 2018, 9, 841-849. https://pubs.rsc.org/en/content/articlelanding/2018/sc/c7sc03712k#!divAbstract
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2017
18. S. Sreedharan, M. R. Gill, E. Garcia, H. K. Saeed, D. Robinson, A. Byrne, A. Cadby, T. E. Keyes, C. Smythe, P. Pellett, J. B. de la Serna, J. A. Thomas, Multimodal super-resolution optical microscopy using a transition metal-based probe provides unprecedented capabilities for imaging both nuclear chromatin and mitochondria, J. Am. Chem. Soc., 2017, 139, 15907–15913. https://pubs.acs.org/doi/abs/10.1021/jacs.7b08772
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17. M. R. Gill, N. Falzone, Y. Du, K. A. Vallis, Targeted radionuclide therapy in combined-modality regimens, Lancet Oncol., 2017, 18, e414–e423.
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(17)30379-0/fulltext
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2016
16. M. R. Gill, S. N. Harun, S. Halder, R. A. Boghozian, K. Ramadan, H. Ahmad, K. A. Vallis, A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition, Sci. Rep., 2016, 6, 31973.
https://www.nature.com/articles/srep31973
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15. M. G. Walker, P. J. Jarman, M. R. Gill, X. Tian, H. Ahmad, P. A. N. Reddy, L. McKenzie, J. A. Weinstein, A. J. R. Meijer, G. Battaglia, C. Smythe and J. A. Thomas, A self-assembled metallomacrocycle singlet oxygen sensitizer for photodynamic therapy, Chem. Eur. J., 2016, 22, 5996-6000. https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201600852
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2015
14. A. Wragg,† M. R. Gill,† L. McKenzie, C. Glover, R. Mowll, X. Su, C. Smythe and J. A. Thomas, Serum albumin binding inhibits nuclear uptake of luminescent metal complex-based DNA imaging probes, Chem. Eur. J., 2015, 21, 11865-11871.
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201501675
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13. V. Ramu,† M. R. Gill,† P. J. Jarman, D. Turton, J. A. Thomas, A. Das and C. Smythe, A cytostatic ruthenium(II)-platinum(II) bis(terpyridyl) anticancer complex that blocks entry into S phase through up-regulating p27KIP1, Chem. Eur. J., 2015, 21, 9185-9197.
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201500561
2014
12. A. Wragg,† M. R. Gill,† D. Turton, H. Adams, C. Smythe, X. Su and J. A. Thomas, Tuning the cellular uptake properties of luminescent heterobimetallic iridium(III)-ruthenium(II) DNA imaging probes, Chem. Eur. J., 2014, 20, 14004-14011.
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201403693
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11. A. Wragg, M. R. Gill, C. J. Hill, X. Su, A. J. H. M. Meijer, C. Smythe and J. A. Thomas, Dinuclear osmium(II) probes for high-resolution visualisation of cellular DNA structure using electron microscopy, Chem. Commun., 2014, 50, 14494-14497 (front cover).
https://pubs.rsc.org/en/content/articlelanding/2014/cc/c4cc05547k#!divAbstract
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10. E. Baggaley, M. R. Gill, N. H. Green, D. Turton, I. V. Sazanovich, S. W. Botchway, C. Smythe, J. W. Haycock, J. A. Weinstein, J. A. Thomas, Dinuclear ruthenium(II) complexes as two-photon, time-resolved emission microscopy probes for cellular DNA, Angew. Chem. Int. Ed., 2014, 53, 3367-3371 (front cover; Faculty of 1000 recommended article).
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201309427
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2013
9. M. R. Gill, D. Cecchin, M. G. Walker, R. S. Mulla, G. Battaglia, C. Smythe and J. A. Thomas, Targeting the endoplasmic reticulum with a membrane-interactive luminescent ruthenium(II) polypyridyl complex, Chem. Sci., 2013, 4, 4512-4519. (referee-recommended "hot article"). https://pubs.rsc.org/en/content/articlelanding/2013/SC/c3sc51725j#!divAbstract
2012
8. M. R. Gill and J. A. Thomas, Ruthenium(II) polypyridyl complexes and DNA: from structural probes to cellular imaging and therapeutics, Chem. Soc. Rev., 2012, 41, 3179-3192.
https://pubs.rsc.org/en/content/articlelanding/2012/CS/c2cs15299a#!divAbstract
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2007-2011 (PhD w. Profs J. Thomas and G. Battaglia):
7. M. R. Gill, H. Derrat, C. Smythe, G. Battaglia and J. A. Thomas, Ruthenium(II) metallo-intercalators: DNA imaging and cytotoxicity, ChemBioChem, 2011, 12, 877-880 (a ChemBioChem “most cited” article 2012-13).
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201000782
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6. X. Tian, M. R. Gill, I. Canton, J. A. Thomas and G. Battaglia, Live cell luminescence imaging as a function of delivery mechanism, ChemBioChem, 2011, 12, 548-551. https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201000743
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5. A. Ghosh, P. Das, M. R. Gill, P. Kar, M. G. Walker, J. A. Thomas and A. Das, Photoactive RuII–Polypyridyl Complexes that Display Sequence Selectivity and High-Affinity Binding to Duplex DNA through Groove Binding, Chem. Eur. J., 2011, 17, 2089-2098 (inside cover). https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201002149
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4. P. Waywell, V. Gonzalez, M. R. Gill, H. Adams, A. J. H. Meijer, M. P. Williamson and J. A. Thomas, Structure of the Complex of [Ru(tpm)(dppz)py]2+ with a B-DNA Oligonucleotide - A Single-Substituent Binding Switch for a Metallo-Intercalator, Chem. Eur. J., 2010, 16, 2407-2417. (inside cover). https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.200901758
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3. M. R. Gill, J. Garcia-Lara, S. J. Foster, C. Smythe, G. Battaglia and J. A. Thomas, A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells, Nature Chem., 2009, 1, 662-667. https://www.nature.com/articles/nchem.406
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2. S. P. Foxon, T. Phillips, M. R. Gill, M. Towrie, A. W. Parker, M. Webb and J. A. Thomas, A Multifunctional Light Switch: DNA Binding and Cleavage Properties of a Heterobimetallic Ruthenium-Rhenium Dipyridophenazine Complex, Angew. Chem. Int. Ed., 2007, 46, 3686-3688. https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.200604837
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BSc:
1. C. J. Adams, J. P. H. Charmant, N. G. Connelly, M. Gill, A. Kantacha, S. Onganusorn and A. G. Orpen, Homobinuclear cyanide-bridged linkage isomers containing the redox-active unit [([μ]-XY)Ru(CO)2L(o-O2C6Cl4)] (XY = CN or NC), Dalton Trans., 2007, 2283-2294. https://pubs.rsc.org/en/content/articlelanding/2007/dt/b700648a#!divAbstract
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Book chapters:
M. R. Gill and J. A. Thomas, Targeting cellular DNA with luminescent ruthenium(II) polypyridyl complexes, in Ruthenium Complexes - Photochemical and Biomedical Applications, eds. A. Holder, J. L. Bullock, M. A. Lawrence, W. R. Browne and L. Lilge, Wiley-VCH, 2018.